Exploring chromosome folding, genome architecture, and their impact on disease
Revealing how DNA is organized inside cells and how that organization can be leveraged to understand and treat disease.
Our lab investigates how chromosomes fold inside the nucleus and how this 3D architecture controls genome function. We study protein machines like cohesin and condensin that organize DNA at different scales, from local loops to whole chromosome territories, revealing the rules that shape genome stability and gene regulation.
Disruptions in genome folding can cause developmental disorders such as Cornelia de Lange Syndrome. We connect basic discoveries about chromosome architecture to disease mechanisms, with the goal of identifying new ways to “drug the 3D genome” and restore proper gene regulation.
We develop cutting-edge imaging tools, including continued improvements to Oligopaints and our high-throughput HiDRO platform, to map genome organization in single cells at scale. These technologies power genome imaging and genome-wide screens that uncover new regulators of nuclear architecture and provide methods broadly used by the research community.
Please send an email to Eric describing your research interests, along with a copy of your CV
The Joyce Lab at UPENN 