We conduct chromosome dynamics research within the Department of Genetics and Epigenetics Institute at the University of Pennsylvania School of Medicine. Our primary goals are to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability and disease.
Chromosome Folding
The major feature that stands out in the nucleus of all metazoan genomes are the chromosome territories (CTs), which have nonrandom radial positions that are conserved through evolution. We are using our custom Oligopaint FISH probes to identify signatures of chromosome arrangement