We study the spatial organization of the genome within the Department of Genetics and Epigenetics Institute at the University of Pennsylvania School of Medicine.
We use a combination of cellular, molecular, genetic, and computational tools to elucidate how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability and disease. We also develop and utilize new technologies that use fluorescent in situ hybridization (FISH) to interrogate chromosome structure at single-cell resolution. These include a new type of probe, called Oligopaints, which reduces the cost and increases the resolution of FISH and our recently developed pipeline for high-throughput DNA or RNA labeling with Oligopaints (HiDRO).