Research

While the DNA sequence provides the blueprint of the genome, it does not fully explain how genes are controlled. We now know that the way our genomes are organized in three dimensions within each cell plays a critical role in regulating gene activity. Our research focuses on uncovering these principles. Explore our research areas below.

Chromosome Looping and Nuclear Compartments

Our lab investigates how chromosomes fold inside the nucleus and how this 3D architecture controls genome function. We study protein machines like cohesin and condensin that organize DNA at different scales, from local loops to whole chromosome territories, revealing the rules that shape genome stability and gene regulation.

Genome Organization in Development and Disease

Disruptions in genome folding can cause developmental disorders such as Cornelia de Lange Syndrome. We connect basic discoveries about chromosome architecture to disease mechanisms, with the goal of identifying new ways to “drug the 3D genome” and restore proper gene regulation.

Technologies for Spatial Genomics and Screening

We develop cutting-edge imaging tools, including continued improvements to Oligopaints and our high-throughput HiDRO platform, to map genome organization in single cells at scale. These technologies power genome imaging and genome-wide screens that uncover new regulators of nuclear architecture and provide methods broadly used by the research community.